Term Name: aspartic-type endopeptidase activity
Synonyms: aspartate protease activity, aspartic endopeptidase activity, aspartic protease activity, aspartyl protease activity, carboxyl protease activity
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Ontology: GO: Molecular Function [GO:0004190]    QuickGO    AmiGO

Relationships
is a type of: aspartic-type peptidase activity endopeptidase activity
has subtype: aspartic endopeptidase activity, intramembrane cleaving aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negatively regulated by: aspartic-type endopeptidase inhibitor activity