Term Name: | alkylbase DNA N-glycosylase activity |
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Synonyms: | 3-methyladenine DNA glycosylase II, AlkA, alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine), alkylbase DNA glycosidase activity, deoxyribonucleate 3-methyladenine glycosidase II, DNA glycosidase II activity, DNA-3-methyladenine glycosidase II activity, DNA-3-methyladenine glycosylase II |
Definition: | Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. |
Ontology: | GO: Molecular Function [GO:0003905] QuickGO AmiGO |