Term Name: | Gi/o-coupled serotonin receptor activity |
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Synonyms: | 5-HT1 receptor activity, serotonin receptor activity, coupled via Gi/o |
Definition: | Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels. |
Ontology: | GO: Molecular Function [GO:0001586] QuickGO AmiGO |