Term Name: | Hrd1p ubiquitin ligase complex |
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Synonyms: | HRD1 ubiquitin ligase complex |
Definition: | A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78). |
Ontology: | GO: Cellular Component [GO:0000836] QuickGO AmiGO |