Term Name: | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity |
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Synonyms: | bifunctional DNA glycosylase, DNA glycosylase/AP-lyase, DNA glycosylase/beta-lyase, endodeoxyribonuclease III, endonuclease III, endonuclease VIII activity, oxidized pyrimidine base lesion DNA N-glycosylase activity, pyrimidine-specific oxidized base lesion DNA N-glycosylase activity |
Definition: | Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. |
Ontology: | GO: Molecular Function [GO:0000703] QuickGO AmiGO |