Term Name: | nuclear exosome (RNase complex) |
---|---|
Synonyms: | eukaryotic exosome multienzyme ribonuclease complex, nuclear exosome (ribonuclease complex), nuclear exosome multienzyme ribonuclease complex |
Definition: | A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
Ontology: | GO: Cellular Component [GO:0000176] QuickGO AmiGO |