Term Name:	immunodeficiency 53
Synonyms:	IMD53
Definition:	A combined T cell and B cell immunodeficiency characterized by recurrent upper and lower respiratory infections, increase in the CD4+ T cell to CD8+ T cell ratio, impaired T-cell proliferative responses to multiple antigens, and impaired ability to produce specific immunoglobulins that has_material_basis_in homozygous or compound heterozygous mutation in the RELB gene on chromosome 19q13.32.
Ontology:	Human Disease [DOID:0111992]   ( DOID:0111992 )