Term Name: | CIC-rearranged sarcoma |
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Synonyms: | Capicua transcriptional repressor (CIC)-rearranged sarcoma |
Definition: | An EWSERI-negative small round cell tumor that is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and either DUX4 gene on chromosome 4 or DUX4L gene on chromosome 10. The translocation results in either CIC-DUX4, t(4;19)(q35;q13) or CIC-DUX4L, t(10;19)(q26;q13) fusions. |
Ontology: | Human Disease [DOID:0081250] ( DOID:0081250 ) |