Term Name: early pro-B cell
Synonyms:
Definition: A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage.
Ontology: Cell Ontology [CL:0002046]

Relationships
develops into: late pro-B cell
is a type of: pro-B cell
has_low_plasma_membrane_amount: neprilysin
has_plasma_membrane_part: ADP-ribosyl cyclase 1 B-cell receptor CD22 CD34 molecule pre-B cell receptor complex
lacks_plasma_membrane_part: CD19 molecule complement receptor type 2 membrane-spanning 4-domains subfamily A member 1
participates_in: immunoglobulin heavy chain V-D-J recombination