Term Name: marginal zone B cell
Synonyms: marginal zone B lymphocyte, marginal zone B-cell, marginal zone B-lymphocyte, MZ B cell, MZ B lymphocyte, MZ B-cell, MZ B-lymphocyte
Definition: A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high.
Ontology: Cell Ontology [CL:0000845]

Relationships
is part of: marginal zone of spleen
is a type of: mature B cell splenocyte
capable_of: defense response to bacterium
has_high_plasma_membrane_amount: IgM immunoglobulin complex
has_plasma_membrane_part: complement receptor type 2 membrane-spanning 4-domains subfamily A member 1
lacks_plasma_membrane_part: complement component C1q receptor low affinity immunoglobulin epsilon Fc receptor