Term Name: osteoclast
Synonyms: chondroclast
Definition: A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.
Ontology: Cell Ontology [CL:0000092]

Relationships
develops from: monocyte
is part of: bone element
is a type of: bone cell myeloid leukocyte
has subtype: mononuclear osteoclast multinuclear osteoclast odontoclast
capable_of: bone resorption
has_part: cathepsin K nuclear factor NF-kappa-B p100 subunit proto-oncogene c-Fos tartrate-resistant acid phosphatase type 5 transcription factor PU.1
has_plasma_membrane_part: macrophage colony-stimulating factor 1 receptor tumor necrosis factor receptor superfamily member 11A