Term Name: | Kupffer cell |
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Synonyms: | hepatic macrophage, littoral cell of hepatic sinusoid, liver macrophage, macrophagocytus stellatus, stellate cell of von Kupffer, von Kupffer cell |
Definition: | A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. |
Ontology: | Cell Ontology [CL:0000091] |