| Synonyms: |
(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid,
(1R,4S,5S,6S)-4-amino-2,2-dioxo-2lambda(6)-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid,
(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide,
LY 404039,
LY-404,039,
LY-404039,
LY404039,
pomaglumetad
|
| Definition: |
An organic heterobicyclic compound that is (1S,5R)-2-thiabicyclo[3.1.0]hexane carrying oxo, oxo, amino, carboxy, and carboxy groups at positions 2, 2, 4S, 4S, and 6S, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 mGluR3 (Ki = 149 nM and 92 nM, respectively) and exhibits antipsychotic and anxiolytic efficacy in animal models. |