Term Name: | YK-4-279 |
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Synonyms: | 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one, 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one, 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one, YK 4-279, YK 4279, YK4279 |
Definition: | A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by hydroxy, 2-(4-methoxyphenyl)-2-oxoethyl, chloro, and chloro groups at positions 3, 3, 4, and 7, respectively. It blocks RNA helicase A binding to EWS-FLI1, induces apoptosis, and exhibits antineoplastic activity. |
Ontology: | ChEBI [CHEBI:94301] ( EBI ) |