Term Name: Ro 25-6981
Synonyms: (alphaR,betaS)-alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol, 4-[(1R,2S)-1-hydroxy-2-methyl-3-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, Ro 25-6981 free base, Ro-25-6981, Ro25-6981
Definition: A member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor.
Ontology: ChEBI [CHEBI:92897]  ( EBI )

Relationships
is a type of: benzenes phenols piperidines secondary alcohol tertiary amino compound
has_role: anticonvulsant antidepressant neuroprotective agent NMDA receptor antagonist
inverse is_conjugate_acid_of: Ro 25-6981(1+)
is_conjugate_base_of: Ro 25-6981(1+)