Term Name:	MCB-613
Synonyms:	(2E,6E)-4-ethyl-2,6-bis(3-pyridylmethylene)cyclohexan-1-one, (2E,6E)-4-ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone, MCB 613, MCB613
Definition:	A cyclic ketone that is 4-ethylcyclohexanone which is substituted by pyridin-3-ylmethylene groups at positions 2 and 6. It is a potent small molecule stimulator of steroid receptor coactivators (SRCs). MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species. Since cancer cells overexpress SRCs and rely on them for growth, MCB-613 can be used to selectively induce excessive stress in cancer cells.
Ontology:	ChEBI [CHEBI:90954]  ( EBI )