Term Name: | WIN 18446 |
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Synonyms: | Fertilysin, Fertilysine, N,N'-1,8-Octanediylbis(2,2-dichloroacetamide), N,N'-bis(dichloracetyl)-1,8-octanediamine, N,N'-bis(dichloroacetyl)-1,8-diaminooctane, N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine, N,N'-octamethylenebis(2,2-dichloro-N-ethylacetamide), N,N'-octamethylenebis(2,2-dichloroacetamide), N,N'-octane-1,8-diylbis(2,2-dichloroacetamide), WIN 18,446, Win-18446, WIN18446 |
Definition: | A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis. It down-regulates sex related genes in zebrafish. |
Ontology: | ChEBI [CHEBI:90441] ( EBI ) |