Term Name: CD437
Synonyms: 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid, 6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]-2-naphthalenecarboxylic acid, 6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]naphthalene-2-carboxylic acid, AHPN, Apoptosis Activator VI, Cd 437, CD-437
Definition: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)gamma and induces cell cycle arrest and apoptosis in various cancer cells.
Ontology: ChEBI [CHEBI:88334]  ( EBI )

Relationships
is a type of: adamantanes monocarboxylic acid naphthoic acid phenols
has_role: apoptosis inducer retinoic acid receptor gamma agonist
inverse has_functional_parent: adapalene