Term Name: | CK-666 |
---|---|
Synonyms: | 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide, CK 666, CK-0944666, CK666 |
Definition: | A member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. |
Ontology: | ChEBI [CHEBI:78843] ( EBI ) |