Term Name: proglumetacin
Synonyms: 3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate, proglumetacin, proglumetacina, proglumetacine, proglumetacinum
Definition: A carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining.
Ontology: ChEBI [CHEBI:76263]  ( EBI )

Relationships
is a type of: aromatic ether benzamides carboxylic ester monochlorobenzenes N-acylindole N-alkylpiperazine
has_functional_parent: indometacin proglumide
has_role: antipyretic EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor lipoxygenase inhibitor non-narcotic analgesic non-steroidal anti-inflammatory drug prodrug
inverse has_part: proglumetacin dimaleate