Term Name: | 6-aminonicotinamide |
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Synonyms: | 2-amino-5-carbamoylpyridine, 6-amino-3-pyridinecarboxamide, 6-aminonicotinamide, 6-aminonicotinic acid amide, 6-Aminonikotinsaeureamid, 6-AN, 6-ANA, SR 4388 |
Definition: | A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. |
Ontology: | ChEBI [CHEBI:74514] ( EBI ) |