Term Name: | leuprolide |
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Synonyms: | (D-Leu(6),des-Gly-NH2(10),Pro-ethylamide(9))-gonadotropin-releasing hormone, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide, L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide, Leuprorelin, leuprorelina, leuproreline, leuprorelinum, pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5, pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt |
Definition: | An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. |
Ontology: | ChEBI [CHEBI:6427] ( EBI ) |