Term Name: | 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol |
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Synonyms: | 1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)triphenol |
Definition: | A pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. |
Ontology: | ChEBI [CHEBI:64110] ( EBI ) |