Term Name: | 7-chlorokynurenic acid |
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Synonyms: | 7-chloro-4-hydroxy-2-carboxyquinoline, 7-chloro-4-hydroxyquinoline-2-carboxylic acid, 7-CKA, 7-Cl-KYNA |
Definition: | A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid. |
Ontology: | ChEBI [CHEBI:63965] ( EBI ) |