Term Name: pemetrexed
Synonyms: N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid, pemetrexed
Definition: An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Ontology: ChEBI [CHEBI:63616]  ( EBI )

Relationships
is a type of: N-acyl-L-glutamic acid pyrrolopyrimidine
has_role: antimetabolite antineoplastic agent EC 1.5.1.3 (dihydrofolate reductase) inhibitor EC 2.1.1.45 (thymidylate synthase) inhibitor EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
inverse is_conjugate_base_of: pemetrexed(2-)
is_conjugate_acid_of: pemetrexed(2-)