Term Name: aprepitant
Synonyms: 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-Delta(2)-1,2,4-triazolin-5-one, 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, aprepitant, aprepitantum
Definition: A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.
Ontology: ChEBI [CHEBI:499361]  ( EBI )

Relationships
is a type of: (trifluoromethyl)benzenes cyclic acetal morpholines triazoles
has_role: antidepressant antiemetic neurokinin-1 receptor antagonist peripheral nervous system drug substance P receptor antagonist