Term Name: fabesetron
Synonyms: (+)-(R)-8,9-dihydro-10-methyl-7-((5-methylimidazol-4-yl)methyl)pyrido[1,2-a]indol-6(7H)-one, (7R)-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]-8,9-dihydropyrido[1,2-a]indol-6(7H)-one, fabesetron, fabesetronum, FK 1052, FK-1052, FK1052
Definition: An organic heterotricyclic compound that is 8,9-dihydropyrido[1,2-a]indol-6(7H)-one substituted by a (5-methyl-1H-imidazol-4-yl)methyl group at position 7R and a methyl group at position 10. It is a dual 5-HT3 and 5-HT4 receptors antagonist whose clinical development was terminated in phase II. It was being developed for the treatment of chemotherapy-induced emesis and irritable bowel syndrome.
Ontology: ChEBI [CHEBI:31588]  ( EBI )

Relationships
is a type of: imidazoles organic heterotricyclic compound
has_role: antiemetic serotonergic antagonist