Term Name: | JHU083 |
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Synonyms: | ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate, ethyl (2S)-2-{[(2S)-2-amino-4-methylpentanoyl]amino}-6-diazo-5-oxohexanoate, ethyl (S)-2-((S)-2-amino-4-methylpentanamido)-6-diazo-5-oxohexanoate, ethyl L-leucyl-6-diazo-5-oxo-L-norleucinate, JHU 083, JHU-083 |
Definition: | An ethyl ester resulting from the formal condensation of the carboxy group of L-leucyl-6-diazo-5-oxo-L-norleucine with ethanol. It is a glutaminase inhibitor and a prodrug of 6-diazo-5-oxo-L-norleucine that exhibits antineoplastic activity. |
Ontology: | ChEBI [CHEBI:232049] ( EBI ) |