Term Name: LLY-507
Synonyms: 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl][biphenyl]-3-carboxamide, LLY 507, LLY507
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}[biphenyl]-3-carboxylic acid with the amino group of 3-(pyrrolidin-1-yl)propan-1-amine. It is a potent and selective inhibitor of SMYD2 and inhibits the ability of SMYD2 to methylate p53. It serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.
Ontology: ChEBI [CHEBI:228258]  ( EBI )

Relationships
is a type of: benzamides methylindole N-alkylpiperazine N-alkylpyrrolidine N-arylpiperazine nitrile secondary carboxamide
has_role: EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitor