Term Name: alkylating agent
Synonyms:
Definition: Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases.
Ontology: ChEBI [CHEBI:22333]  ( EBI )

Relationships
is a type of: mutagen
inverse has_role: 1,2-dimethylhydrazine 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 2,5-bis(aziridin-1-yl)-1,4-benzoquinone 2-aminoacrylic acid 2-chloroethyl methanesulfonate 2-fluoroethyl methanesulfonate 3-bromopyruvic acid 4-hydroperoxycyclophosphamide 4-hydroxycyclophosphamide acrylamide anthramycin apholate aziridine bis(2-chloroethyl) sulfide bis(chloromethyl) ether bromoethane busulfan carmustine chlorambucil chloroacetic acid colibactin cyclophosphamide cyclophosphamide hydrate D-mannitol 1,6-bis(methanesulfonate) dacarbazine diaziquone diazomethane diethyl sulfate dimethyl sulfate dimethyl sulfoxide dimethylmyleran esperamicin A1 estramustine etanidazole ethyl methanesulfonate evofosfamide fotemustine hex-3-yne-2,5-diyl bis(methanesulfonate) hexane-2,5-diyl bis(methanesulfonate) hycanthone mesylate ifosfamide iodoacetic acid L-mannitol 1,6-bis(methanesulfonate) lomustine mechlorethamine melphalan methyl methanesulfonate mitomycin A mitomycin C MTIC N-ethyl-N-nitrosourea N-methyl-N'-nitro-N-nitrosoguanidine N-methyl-N-nitrosourea N-tosyl-L-phenylalanyl chloromethyl ketone nimustine nitrogen mustard pipobroman S-(chloromethyl)glutathione semustine temozolomide tilimycin tomaymycin trabectedin tretamine triaziquone trimethyl phosphite