Term Name:	SYC-435
Synonyms:	1-hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone, 1-hydroxy-4-methyl-6-benzyl-2(1H)-pyridone, 6-benzyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one, 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one, 6-benzyl-1-hydroxy-4-methylpyridin-2-one, 6-benzyl-4-methyl-1-hydroxypyridin-2(1H)-one, SYC 435, SYC435, TC-E 5008
Definition:	A cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and benzyl groups, respectively. It is a potent inhibitor of mutant isocitrate dehydrogenase 1 (Ki values of 190 nM against R132H mutant and 120 nM against R132C mutant).
Ontology:	ChEBI [CHEBI:189826]  ( EBI )