Term Name: 2,8-dihydroxyadenine
Synonyms: 2,8-DHA, 6-amino-2,8-dihydroxypurine, 6-amino-9H-purine-2,8-diol, 6-amino-purine-2,8-diol
Definition: A member of the class of 6-aminopurines that is adenine bearing two hydroxy substituents at positions 2 and 8. It is a highly insoluble metabolite of adenine that causes radiolucent urolithiasis. It is produced by individuals who suffer from adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive error of purine metabolism.
Ontology: ChEBI [CHEBI:183641]  ( EBI )

Relationships
is a type of: 6-aminopurines diol heteroaryl hydroxy compound
has_functional_parent: adenine
has_role: human urinary metabolite mouse metabolite nephrotoxic agent
inverse is_tautomer_of: 2,8-dioxoadenine
is_tautomer_of: 2,8-dioxoadenine