Term Name: | 2,8-dihydroxyadenine |
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Synonyms: | 2,8-DHA, 6-amino-2,8-dihydroxypurine, 6-amino-9H-purine-2,8-diol, 6-amino-purine-2,8-diol |
Definition: | A member of the class of 6-aminopurines that is adenine bearing two hydroxy substituents at positions 2 and 8. It is a highly insoluble metabolite of adenine that causes radiolucent urolithiasis. It is produced by individuals who suffer from adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive error of purine metabolism. |
Ontology: | ChEBI [CHEBI:183641] ( EBI ) |