Term Name: LFM-A13
Synonyms: (2Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide, (2Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide, 2Z-cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide, alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide, DDE-28
Definition: An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the amino group of 2,5-dibromoaniline. It is a dual-function inhibitor of Bruton's tyrosine kinase (BTK) and Polo-like kinases (PLK) that exhibits anticancer properties.
Ontology: ChEBI [CHEBI:183517]  ( EBI )

Relationships
is a type of: aromatic amide dibromobenzene enamide enol nitrile secondary carboxamide
has_role: antineoplastic agent apoptosis inducer EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor EC 2.7.11.21 (polo kinase) inhibitor geroprotector platelet aggregation inhibitor