Term Name: brivanib alaninate
Synonyms: (1R,2S)-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester, (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aminopropanoate, (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl L-alaninate, alaninate de brivanib, alaninati brivanibum, alaninato de brivanib, BMS 582664, BMS-582664, BMS582664, brivanib alaninate
Definition: A carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas.
Ontology: ChEBI [CHEBI:167656]  ( EBI )

Relationships
is a type of: aromatic ether carboxylic ester diether fluoroindole L-alanine derivative pyrrolotriazine
has_functional_parent: brivanib
has_role: angiogenesis inhibitor antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor fibroblast growth factor receptor antagonist prodrug