Term Name: | dextromethadone |
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Synonyms: | (+)-(S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone, (+)-methadone, (6S)-6-(dimethylamino)-4,4-diphenylheptan-3-one, (6S)-methadone, (S)-(+)-methadone, (S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone, (S)-methadone, d-6-(dimethylamino)-4,4-diphenyl-3-heptanone, d-methadone, REL-1017, S-(+)-methadone, S-methadone |
Definition: | A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. |
Ontology: | ChEBI [CHEBI:167308] ( EBI ) |