Term Name: | holomycin |
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Synonyms: | 6-(acetylamino)-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one, 6-acetamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one, N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3-b]pyrrol-6-yl)acetamide, N-(5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide, N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide, N-demethylthiolutin, N-{5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}acetamide |
Definition: | A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. |
Ontology: | ChEBI [CHEBI:156451] ( EBI ) |