Term Name: | G-15 |
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Synonyms: | (3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline, G 15, G15 |
Definition: | An organic heterotricyclic compound that is 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline substituted by a 6-bromo-1,3-benzodioxol-5-yl group at position 4 (the 3aS,4R,9bR-stereoisomer). It is a high affinity and selective GPER1 receptor antagonist (Ki = 20 nM) which inhibits the anti-depressive effects of estrogen in vivo. |
Ontology: | ChEBI [CHEBI:156295] ( EBI ) |