Term Name: | bis(7)-tacrine |
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Synonyms: | B7T, bis(7)-tetrahydroaminacrine, heptylene-bis(tacrine), N,N'-bis(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine, N,N'-di(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine |
Definition: | A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells. |
Ontology: | ChEBI [CHEBI:138435] ( EBI ) |