Term Name: plerixafor
Synonyms: 1,1'-(benzene-1,4-diyldimethanediyl)bis(1,4,8,11-tetraazacyclotetradecane), 1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane), 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane, AMD 3100, AMD-3100, AMD3100, JKL 169, JM3100, Mozobil, plerixafor, plerixaforum, SDZ SID 791
Definition: An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
Ontology: ChEBI [CHEBI:125354]  ( EBI )

Relationships
is a type of: azacycloalkane azamacrocycle benzenes crown amine secondary amino compound tertiary amino compound
has_functional_parent: 1,4,8,11-tetraazacyclotetradecane
has_role: anti-HIV agent antineoplastic agent C-X-C chemokine receptor type 4 antagonist immunological adjuvant